Lennie is a big and dumb man, George is a small and smart guy. These two man travel together, they come from a ranch up north in Weed. They’re going to work at another ranch because they had to escape the ranch in Weed. Lennie likes mice, he keeps a dead mouse in his pocket, George doesn’t let Lennie keep this mouse because it’s not fresh. Lennie likes to pet the mice, they’re really soft, but he always pets them too hard and he kills them. Lennie isn’t a big help to George; he loses jobs and gets in to trouble. In Weed he got into trouble when Lennie wanted to pet the dress of a girl, the girl was afraid of Lennie and didn’t know it was just her dress Lennie was after. Their dream is to have a little farm of their own, with rabbits Lennie would tend.
When they arrive at the ranch they meet their boss and also the son of the boss; Curley, Curley doesn’t seem to be fond of Lennie, he hates big guys because he’s a little guy himself. Curley just got married a few weeks ago. When they meet his wife, Lennie thinks she’s very pretty but George warns him to stay away from her, otherwise they’ll get into trouble again. They meet Slim, a really nice jerk line skinner that has some puppies. Lennie really wants a puppy to pet instead of mice and he gets a puppy. George tells Slim the story of him and Lennie; he used to tease Lennie a lot but Lennie, big as he was, never harmed him. George has stopped doing that now. George also tells Slim the reason they fled the ranch in Weed. One of the workers; Carlson insists on shooting an old dog that belongs to Candy; a really old man with only one hand, because this dogs smells really bad. Candy doesn’t want this but eventually gives in. George and Lennie tell Candy, the old man, about their dream of having a little farm for themselves. Candy wants to join them; he can put in 300 dollars, they need 600 dollars. The three of them make a plan; next month their dream will come true.